Mpox is a viral infection caused by a virus from the family of orthopoxviruses which include smallpox. The most notable symptom of mpox is a rash that can occur on the hands, feet, chest, face, mouth, or areas around the genitals. Mpox is spread through close intimate or sexual contact with an infected person. Thankfully, there’s a vaccine to protect against mpox. This fact sheet provides information about mpox and mpox vaccines.