In the wake of the COVID-19 pandemic and other outbreaks of vaccine-preventable diseases, vaccines have never been more important around the world and in the state of Colorado. This report explains how Colorado is doing compared to other states in the U.S. and how school districts and senate districts compare to each other. It also explains what vaccine exemptions look like in Colorado, outlines the cost of preventable diseases in our state, and shares information on recent disease outbreaks in Colorado and across the country.