A review of adverse events following vaccination against COVID-19 with mRNA vaccines in the USA confirms that most side effects were mild and decreased substantially after one day. The new study, published in The Lancet Infectious Diseases journal, suggests that for more than 298 million vaccine doses administered between December 2020 and June 2021, 92% (313,499/340,522) of reported adverse events were not serious, and less than 1% of v-safe participants reported seeking any medical care following vaccination.
In December 2020 two mRNA COVID-19 vaccines – Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1723) – were authorised for emergency use in the USA. Both vaccines involved two primary doses and have shown good safety profiles in clinical trials, with mild effects such as injection site pain, fatigue, and headache being reported as the most common adverse events.
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