From June 23 to July 24, Immunize Colorado ran a Facebook ad campaign to promote the safety, efficacy, and importance of COVID-19 vaccination to Coloradans, with specific focus on those in rural areas and communities of color. The campaign was made possible by the World Health Organization’s Vaccine Safety Net, of which Immunize Colorado is a member, and their partnership with the Facebook Health Partnerships team. The campaign reached nearly 700,000 Coloradans, garnered 5.6 million impressions, and prompted over 30,000 clicks, which directed users to sign up for vaccine appointments. Immunize Colorado has made available the campaign creative for others to utilize in their own COVID-19 promotion efforts.